Donohoe is probably best known as the actress playing C.J., the bisexual lawyer, on the TV drama L.A. Law. In the horror film, Lair of the White Worm, Donohoe played a reincarnated pagan priestess who belonged to a snake-worshipping cult stamped out by the early Christians. A controversial scene in the film required Donohoe's character to spit venom on a crucifix. When a reporter from Interview magazine asked her about the scene, Donohoe replied, "I'm an atheist, so it was actually a joy. Spitting on Christ was a great deal of fun. I can't embrace a male god who has persecuted female sexuality throughout the ages. And that persecution still goes on today all over the world."